FB2026_02 , released June 18, 2026
Allele: Dmel\eIF5BΔ1
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General Information
Symbol
Dmel\eIF5BΔ1
Species
D. melanogaster
Name
FlyBase ID
FBal0121838
Feature type
allele
Associated gene
Dmel\eIF5B
Associated Insertion(s)
P{?lacW}eIF5BΔ1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Carrera et al., 2000)
Progenitor genotype
P{lacW}L3659
(Carrera et al., 2000)
Associated Insertion(s)
P{?lacW}eIF5BΔ1
Cytology
Description

Imprecise excision of the P{lacW} element in which 440bp of genomic DNA is replaced with 41bp of P-element sequence, resulting in a deletion which removes the first 27 codons.

(Carrera et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Large homozygous female germline clones cannot be recovered.

      (Carrera et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      eIF5BΔ1/eIF5B[+] is an enhancer of some die during embryonic stage | maternal effect phenotype of vasPH165

      (Carrera et al., 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The frequency of unhatched embryos produced by vasPH165/+ females at 29oC is increased by addition of one copy of eIF5BΔ1 or Df(3L)G5. Many embryos from vasPH165/+ ; eIF5BΔ1/+ mothers show severe segmentation defects and 26% show a vas-like phenotype in which the 4th abdominal segment is completely or partially deleted (partial or total deletion of A4 is never seen in the progeny of either single heterozygote). There is a marked reduction in the number of pole cells in embryos derived from double heterozygotes, and occasionally pole cells are completely absent. The pole cells are often interspersed with or positioned beneath somatic cells.

      (Carrera et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cIF2Δ1
      dIF2Δ1
      (Carrera et al., 2000)
      eIF5BΔ1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)