FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\WASp2
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General Information
Symbol
Dmel\WASp2
Species
D. melanogaster
Name
FlyBase ID
FBal0121874
Feature type
allele
Associated gene
Dmel\WASp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    A 10 nucleotide deletion between positions 24651754-24651744. Missing sequence is: agtcagtgcgc. This results in frameshift after residue Pro-373 of the protein and termination after 114 additional residues.

    (Schejter, 2006.7.3)

    Small intragenic deletion resulting in a predicted frameshift which causes the cytoskeleton-interacting carboxy-terminal domain to be lost.

    (Ben-Yaacov et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    delins
    3R:28,826,284..28,826,291 [-]
    Inserted_sequence:

    GGTG

    Comment:

    Replacement of 8nt (CGGAAACA), with 4 nt (GGTG). This results in a frameshift after residue Pro-309 of the WASp protein and early translation termination after the addition of 120 novel residues.

    (Schejter, 2006.7.3, Ben-Yaacov et al., 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Hemizygotes complete nearly all stages of imaginal development and die as young adults, most commonly failing to eclose from the pupal case. Those that eclose can survive for a few days, but are lethargic and passive in their behaviour.

        (Ben-Yaacov et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Availability

        Stated to be lost.

        (Schejter, 2006.7.3)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        WASp2
        (Schejter, 2006.7.3)
        Wsp2
        (Ben-Yaacov et al., 2001)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)