FlyBase Allele Report: Dmel\ptc[CΔ.UAS]

General Information

Symbol

Dmel\ptc^CΔ.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0124966

Feature type

allele

Associated gene

Dmel\ptc

Associated Insertion(s)

Carried in Construct

P{UAS-ptc.CΔ}

Key Links

Transgenic product class

inframe_deletion

(Johnson et al., 2000)

stop_gained

(Johnson et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Johnson et al., 2000)

stop_gained

(Johnson et al., 2000)

Mutagen

in vitro construct

(Johnson et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-ptc.CΔ}

Cytology

Description

UASt sequences drove expression of ptc that has had amino acids 9 to 676 deleted and a stop codon and an XbaI site introduced after codon 1130. There are also 12 unrelated amino aids at the C terminus.

(Johnson et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ptc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^71B

(Johnson et al., 2000)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^71B

(Johnson et al., 2000)

first posterior wing cell, with Scer\GAL4^71B, ptc^N.UAS

(Johnson et al., 2000)

submarginal wing cell, with Scer\GAL4^71B, ptc^N.UAS

(Johnson et al., 2000)

wing, with Scer\GAL4^71B

(Johnson et al., 2000)

wing, with Scer\GAL4^en-e16E, ptc^N.UAS

(Johnson et al., 2000)

wing vein L3, with Scer\GAL4^71B, ptc^N.UAS

(Johnson et al., 2000)

wing vein L3, with Scer\GAL4^en-e16E, ptc^N.UAS

(Johnson et al., 2000)

wing vein L4, with Scer\GAL4^71B, ptc^N.UAS

(Johnson et al., 2000)

wing vein L4, with Scer\GAL4^en-e16E, ptc^N.UAS

(Johnson et al., 2000)

Detailed Description

Statement

Reference

When ptc^CΔ.Scer\UAS is driven by Scer\GAL4^71B wing notching and disrupted anterior crossvein formation is seen. Expression of both ptc^N.Scer\UAS and ptc^CΔ.Scer\UAS when driven by Scer\GAL4^71B causes both mild and severe wing phenotypes in the wing - partial fusion of wing veins 3 and 4 to the deletion of the region between veins 2 and 4. Expression of both ptc^N.Scer\UAS and ptc^CΔ.Scer\UAS when driven by Scer\GAL4^en-e16E leads to a drastic loss of central wing pattern.

(Johnson et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

ptc^CΔ.UAS is partially rescued by ptc^N.UAS/Scer\GAL4^da.G32

(Johnson et al., 2000)

Fails to rescue

Scer\GAL4^71B/ptc^CΔ.UAS fails to rescue ptc^unspecified

(Johnson et al., 2000)

Comments

(with ptc^N.Scer\UAS) Fails to rescue: ptc¹⁶

(Johnson et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

44615

w^*; P{UAS-ptc.CΔ}2B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ptc^CΔ.Scer\UAS

ptc^CΔ.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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