FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pde4221b
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General Information
Symbol
Dmel\Pde4221b
Species
D. melanogaster
Name
FlyBase ID
FBal0125073
Feature type
allele
Associated gene
Dmel\Pde4
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Swan et al., 2001)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nurse cell nuclei are dramatically enlarged compared to wild type. Rare egg chambers containing 31 nurse cells plus one oocyte are seen. Females show egg retention.

      (Swan et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Pde4dnc-M14/Pde4221b has nurse cell | increased number phenotype, non-suppressible by rut[+]/Adcy1rut-2

      (Swan et al., 2001)

      Pde4dnc-M14/Pde4221b has nurse cell & nucleus phenotype, non-suppressible by rut[+]/Adcy1rut-2

      (Swan et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rut2 partially rescues the egg laying defects of dnc221b/dncM14, but fails to rescue the nurse cell nuclear morphology and 32-cell cyst defects.

      (Swan et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pde4221b
      dnc221b
      Name Synonyms
      Secondary FlyBase IDs
        References (1)