FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\HTTQ20.ex1.UAS
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General Information
Symbol
Hsap\HTTQ20.ex1.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0127293
Feature type
allele
Associated gene
Hsap\HTT
Associated Insertion(s)
Carried in Construct
P{UAS-HTT.ex1.Q20}
Also Known As
UAS-Httex1p-Q20, Htt20Q, UAS-htt exon-1-Q20, UAS-20Q, P{UAS-Httex1p Q20}, UAS-Htt exon1-Q20, UAS-httex1p Q20, Httex1p Q20, UAS-Httex1pQ20
Key Links
Transgenic product class
inframe_deletion
(Steffan et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Steffan et al., 2001)
Mutagen
in vitro construct
(Steffan et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-HTT.ex1.Q20}
Cytology
Description

UASt sequences drive expression of Hsap\HTT exon 1 with a polyglutamine repeat of 20 residues.

(Steffan et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\HTT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Slepko et al., 2006)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\HTTQ20.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 does not induce photoreceptor neurodegeneration in the adult eye at 7 days post-eclosion.

      (Chongtham and Agrawal, 2016)

      Flies expressing Scer\GAL4elav-C155>Hsap\HTTQ20.ex1p.Scer\UAS do not show premature death. The survival curve of the Hsap\HTTQ20.ex1p.Scer\UAS-transgenic flies is similar to that of wild-type.

      (Besson et al., 2015)

      The end-systolic diameter (ESD) and end-diastolic diameter (EDD) of 5-day old and 19-day old flies expressing Hsap\HTTQ20.ex1p.Scer\UAS under the control of Scer\GAL4Hand.ΔVM.Switch (limited to the adult stages using 100ug/ml RU486) are similar to controls.

      (Heidari et al., 2015)

      Larval ddaE neurons expressing Hsap\HTTQ20.ex1.UAS under the control of Scer\GAL4221 do not show significant changes in growing microtubules within dendrites, as compared to neurons in controls.

      (Chen et al., 2012)

      Flies expressing Hsap\HTTQ20.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 show similar evoked excitatory junction potential (eEJP) amplitudes recorded at the third instar larval neuromuscular junction at 0.6 or 1.5 mM Ca[2+] concentrations to controls. Miniature excitatory junction potential m(EJP) amplitude distribution are similar to controls.

      (Steinert et al., 2012)

      Expression of Hsap\HTTQ20.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155 results in an increase in the 3-hydroxykynurenine (3-HK)/kynurenic acid (KYNA) ratio as compared to controls. No rhabdomere degeneration is observed.

      (Campesan et al., 2011)

      Scer\GAL4elav-C155-driven expression of Hsap\HDQ20.ex1p.Scer\UAS does not have any adverse effect on survival or longevity of flies.

      (Mallik and Lakhotia, 2009)

      Scer\GAL4repo Hsap\HTTQ20.ex1p.Scer\UAS flies show normal motor activities (negative geotaxis assay) at day 7.

      (Tamura et al., 2009)

      No visible aggregates are observed when Hsap\HDQ20.ex1p.Scer\UAS is expressed under the control of Scer\GAL4ninaE.PD.

      Co-expression of Hsap\HDQ20.ex1p.Scer\UAS with Hsap\HDQ93.ex1p.Scer\UAS under the control of Scer\GAL4ninaE.PD results in an increase of cells with nuclear inclusions at days 5 and 6, compared to expression of just Hsap\HDQ93.ex1p.Scer\UAS alone. By day 10, almost all cell nuclei in flies expressing both Hsap\HDQ20.ex1p.Scer\UAS and Hsap\HDQ93.ex1p.Scer\UAS contain inclusions.

      (Slepko et al., 2006)

      Flies expressing Hsap\HTTQ20.ex1p.Scer\UAS under the control of Scer\GAL4Eaat1.PR show no behavioural defects and have a normal lifespan.

      (Lievens et al., 2005)

      Expression of Hsap\HDQ20.ex1p.Scer\UAS at 25oC, under the regulation of Scer\GAL4elav-C155 does not affect the survival rate. Hsap\HD aggregates are never detected in flies expressing the non-pathogenic Hsap\HDQ20.ex1p.Scer\UAS transgene (under the control of Scer\GAL4elav-C155.

      (Wolfgang et al., 2005)

      When Hsap\HDQ20.ex1p.Scer\UAS is driven by Scer\GAL4Appl.G1a or Scer\GAL4179Y apparently normal neurons are seen. Overexpression of Hsap\HDQ20.ex1p.Scer\UAS has no effect on cell death in neurons.

      (Gunawardena et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Co-expression of Hsap\HDQ20.ex1p.Scer\UAS with Hsap\HDQ93.ex1p.Scer\UAS under the control of Scer\GAL4ninaE.PD results in an increase of cells with nuclear inclusions at days 5 and 6, compared to expression of just Hsap\HDQ93.ex1p.Scer\UAS alone. By day 10, almost all cell nuclei in flies expressing both Hsap\HDQ20.ex1p.Scer\UAS and Hsap\HDQ93.ex1p.Scer\UAS contain inclusions.

      Co-expression of Hsap\HDQ20.ex1p.Scer\UAS with Hsap\HDQ93.ex1p.Scer\UAS under the control of Scer\GAL4ninaE.PD increases the speed and severity of neuronal degeneration compared to expression of Hsap\HDQ93.ex1p.Scer\UAS alone (under the control of Scer\GAL4ninaE.PD), with an average of only 4.7 rhabdomeres per ommatidium remaining.

      (Slepko et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\HDQ20.ex1p.Scer\UAS
      Hsap\HTTQ20.ex1.Scer\UAS
      Hsap\HTTQ20.ex1.UAS
      Hsap\HTTQ20.ex1p.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (36)