FB2026_02 , released June 18, 2026
Allele: Dmel\rsths.18ZΔ3.1
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General Information
Symbol
Dmel\rsths.18ZΔ3.1
Species
D. melanogaster
Name
FlyBase ID
FBal0127893
Feature type
allele
Associated gene
Dmel\rst
Associated Insertion(s)
Carried in Construct
P{ha-rst.18ZΔ3.1}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Strunkelnberg et al., 2001)
Progenitor genotype
Carried in construct
P{ha-rst.18ZΔ3.1}
Cytology
Description

Construct: A secretable extracellular version of rst is driven by a heatshock promoter.

(Strunkelnberg et al., 2001)
Allele components
Component
Use(s)
Encoded product / tool
rst
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A 22-hour heat shock of white prepupae (0 hours APF) carrying rsths.18ZΔ3.1 results in a small but consistent reduction in viability. Persistent larval salivary glands are found in 21-40% of these animals, but only 9% of controls, at 24 hours APF. These persistent salivary glands have large vacuoles indicating that the normal cell death process has been arrested at an early stage.

      (Simon et al., 2009)

      rsths.18ZΔ3.1 is lethal if heatshock induced during stages 12 to 15. In these embryos, the muscles are thinner and more unfused myoblasts can be observed.

      (Strunkelnberg et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rsths.18ZΔ3.1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)