FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fkhhs.PJ
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General Information
Symbol
Dmel\fkhhs.PJ
Species
D. melanogaster
Name
heat shock construct of Jackle
FlyBase ID
FBal0127998
Feature type
allele
Associated gene
Dmel\fkh
Associated Insertion(s)
Carried in Construct
P{hs-fkh.J}
Key Links
Transgenic product class
wild_type
(Renault et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Renault et al., 2001)
Mutagen
in vitro construct
(Renault et al., 2001)
Progenitor genotype
Carried in construct
P{hs-fkh.J}
Cytology
Description

An Hsp70 promoter drives expression of wild-type fkh.

(Renault et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
fkh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of fkhhs.PJ results in the retention of salivary glands at 20APF, approximately 6 hours after the salivary glands are normally destroyed. The structure of the cells and cell nuclei of most rescued salivary glands appears well-preserved, and the overall morphology of the glands is very similar to that of salivary glands before the onset of programmed cell death. In some of the rescued salivary glands, the cells appear to be more round in shape and contain large vacuole-like structures, suggesting that the cell death program has been initiated in these glands. At 26 hours APF, the number of persisting salivary glands is substantially reduced. With sustained heat-shock, an increased number of salivary glands persist at 26 hours APF.

      (Cao et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      H. Jackle M. Hoch

      (Renault et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fkhhs.PJ
      Name Synonyms
      heat shock construct of Jackle
      (Renault et al., 2001)
      Secondary FlyBase IDs
        References (2)