FB2026_02 , released June 18, 2026
Allele: Dmel\Ptp52F7.8.1
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General Information
Symbol
Dmel\Ptp52F7.8.1
Species
D. melanogaster
Name
FlyBase ID
FBal0128127
Feature type
allele
Associated gene
Dmel\Ptp52F
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schindelholz et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: P633S.

(Schindelholz et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,174,153..16,174,153 [-]
Nucleotide change:

C16174153T

Amino acid change:

P632S | Ptp52F-PB

Reported amino acid change:

P633S

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement (Figure 1 sequence).

(Schindelholz et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutants, and hemizygous mutants (over Df(2R)Jp4 or Df(2R)Jp8) show a range of phenotypes in the SNa branch of the segmental nerve. Additional branches are seen at random position, either the posterior of anterior branch is missing, or occasionally in Ptp52F7.8.1/Df(2R)Jp4 the SNa stalls near the bifurcation point. Homozygous mutants, and hemizygous mutants (over Df(2R)Jp4 or Df(2R)Jp8) show a weak phenotype in the ISNb nerve branch. ISNb occasionally stalls in the VLM field. Homozygous mutants, and hemizygous mutants (over Df(2R)Jp4 or Df(2R)Jp8) show a range of phenotypes in the Intersegmental nerve (ISN). ISNs sometimes terminate at the second branchpoint, and occasionally ISN appear to reach the terminal arbor position, but are thin or bifurcated.

      (Schindelholz et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ptp52F7.8.1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)