FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pwn14S7
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General Information
Symbol
Dmel\pwn14S7
Species
D. melanogaster
Name
FlyBase ID
FBal0129137
Feature type
allele
Associated gene
Dmel\pwn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Deletion within the pwn coding region spanning a region of 1348bp and including a 10 nucleotide insertion. This results in a frameshift that is predicted to produce a truncated protein of 622 amino acids.

    (Arruda and Dolph, 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Only 5% of homozygotes survive to adulthood. Mutants show a very rapid light-dependent retinal degeneration and an abnormal electrophysiological response to light. About 50% of the surviving homozygotes have dark brown deposits on their eyes. All the surviving homozygotes have bristles that are about 50% the normal length and taper to a fine point.

        (Arruda and Dolph, 2003)

        Mutant flies exhibit a novel electrophysiological response to light with high-frequency oscillations during photoreceptor cell depolarization. Also exhibit a rapid light-dependent retinal degeneration. Microvilli are selectively lost from the distal tips of the rhabdomeres. In addition mutants show embryonic lethality, truncated bristles, and black melanic deposits on the eyes of mutant flies.

        (Arruda and Dolph, 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        pwn12A

        (Arruda and Dolph, 2003)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        It is possible that the visual system defects seen in pwn14S7 mutants are due to a second-site mutation on the chromosome, since other pwn mutant alleles fully complement the pwn14S7 visual system defects, although if it is a second-site mutation, it must be in a nearby gene to pwn, since the visual system defects are uncovered by Df(2R)sple-D1 and Df(2R)pwn5. Alternatively, pwn14S7 may behave as a recessive gain-of-function allele, in which the truncated gene product in the mutant is responsible for the visual system defects.

        (Arruda and Dolph, 2003)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        pwn14S7
        Name Synonyms
        Secondary FlyBase IDs
          References (2)