FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: HIV-1\Taths.PB
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General Information
Symbol
HIV-1\Taths.PB
Species
L. Human immunodeficiency virus type 1
Name
heat shock construct of Battaglia
FlyBase ID
FBal0131011
Feature type
allele
Associated gene
HIV-1\Tat
Associated Insertion(s)
Carried in Construct
P{hs-HIV-1\Tat.B}
Transgenic product class
cDNA
(Battaglia et al., 2001)
wild_type
(Battaglia et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Battaglia et al., 2001)
wild_type
(Battaglia et al., 2001)
Mutagen
in vitro construct
(Battaglia et al., 2001)
Progenitor genotype
Carried in construct
P{hs-HIV-1\Tat.B}
Cytology
Description

Full length HIV-1\Tat cDNA is expressed under the control of an Hsp70 promoter.

(Battaglia et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
HIV-1\Tat
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HIV-1\Taths.PB results in increased mortality at embryonic and larval stages. Moreover, developmental stages are delayed by four days compared with the control strain.

      (Ponti et al., 2008)

      Expression of HIV-1\Taths.PB during oogenesis using heat shock results in 10-13% of eggs having a single, fused dorsal appendage. Oocytes expressing HIV-1\Taths.PB show a decrease in cytoplasmic streaming which terminates immediately or at most 1 hour after HIV-1\Taths.PB expression, in contrast to control oocytes which are not affected by heat shock and which normally terminate in 2 hours and 30 minutes.

      (Battaglia et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HIV-1\Taths.PB
      Name Synonyms
      heat shock construct of Battaglia
      (Battaglia et al., 2001)
      Secondary FlyBase IDs
        References (2)