The mean lifespan of mutant male and female flies is increased by more than 30% compared to controls. The mutant flies are longer lived than controls under both abundant and restricted food conditions. No further lifespan enhancement is seen in the mutant flies under restricted food conditions compared to abundant food conditions.
Edem1EP1588/α-Man-IEP1628 and Edem1EP1588/α-Man-IEP982 flies have similar lifespan profiles as α-Man-IEP982/α-Man-IEP1628 flies.