FlyBase Allele Report: Dmel\CkIIβ[mbuP1]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\CkIIβ^mbuP1

General Information

Symbol

Dmel\CkIIβ^mbuP1

Species

D. melanogaster

Name

FlyBase ID

FBal0131296

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

DmCk2β^mbuP1

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Jauch et al., 2006, Jauch et al., 2002)

Mutagen

P-element activity

(Kibler et al., 2001)

Progenitor genotype

Associated Insertion(s)

Cytology

Description

Inserted into the 5' non-coding region of the CkIIβ transcription unit.

(Jauch et al., 2006)

P{lacW} element insertion 8bp downstream of CkIIβ exon Ib.

(Jauch et al., 2002)

Insertion of two P{lacW} elements into the 5' region of CkIIβ.

(Kibler et al., 2001)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

reporter enzyme

Tagged with

nuclear protein localization tag

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm

(Akten et al., 2003)

abnormal circadian rhythm (with CkIIβ^And)

(Akten et al., 2003)

abnormal neuroanatomy

(Jauch et al., 2006)

abnormal neuroanatomy (with CkIIβ^mbuΔA26-2L)

(Jauch et al., 2006)

female semi-sterile

(Jauch et al., 2006)

male semi-sterile

(Jauch et al., 2006)

(Jauch et al., 2002)

viable (with CkIIβ^mbuΔA26-2L)

(Bulat et al., 2014)

Phenotype Manifest In

adult mushroom body

(Jauch et al., 2002)

calyx of adult mushroom body

(Jauch et al., 2006, Jauch et al., 2002, Kibler et al., 2001)

calyx of adult mushroom body (with CkIIβ^mbuΔA26-2L)

(Jauch et al., 2006)

(Jauch et al., 2006, Jauch et al., 2002)

neuromuscular junction (with CkIIβ^mbuΔA26-2L)

(Bulat et al., 2014)

synapse (with CkIIβ^mbuΔA26-2L)

(Bulat et al., 2014)

Detailed Description

Statement

Reference

Transheterozygous CkIIβ^mbuP1/CkIIβ^mbuΔA26-2L mutant larvae show a small but significant increase in synaptic retractions and survive to adulthood.

(Bulat et al., 2014)

CkIIβ^mbuP1 fly brains show a reduction in Kenyon cell number, as revealed by the reduced size of the mushroom body calyx, which is approximately half the size of that in wild type flies.

The mushroom body calyx of flies transheterozygous for CkIIβ^mbuP1 and CkIIβ^mbuΔA26-2L is approximately a third of the size of that in wild type flies.

(Jauch et al., 2006)

Mutant hemizygotes have a circadian rhythm of 25.0 hours. Heterozygotes have a circadian rhythm of 24.6 hours. CkIIβ^mbuP1/CkIIβ^And transheterozygotes have a circadian rhythm of 24.6 hours.

(Akten et al., 2003)

All mushroom body structures are dramatically reduced in size in mutant flies. The Kenyon cell layer volume is reduced to about one-third compared to wild type, due to a reduction in Kenyon cell number. The mushroom body calyx is also reduced in size. The structural organisation of the mushroom bodies and their subdivision into lobes is maintained in mutant flies.

(Jauch et al., 2002)

50% reduction of the mushroom body calyx volume in both male and female flies.

(Kibler et al., 2001)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

(Akten et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Comments

Precise excision of the P{lacW} element reverts the mutant mushroom body phenotype.

(Jauch et al., 2002)

Excision of the P-element reverts the partial loss of male and female fertility phenotype.

(Jauch et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CkIIβ^MbuP1

(Bulat et al., 2014)

CkIIβ^mbuP1

DmCK2beta^mbuP1

(Jauch and Raabe, 2003)

DmCK2β^mbuP1

(Jauch et al., 2006)

DmCk2β^mbuP1

(Jauch et al., 2002)

mbu^P1

(Kibler et al., 2001)

mushroom bodies undersized^P1

(Jauch and Raabe, 2003, Jauch et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections