FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mes2KG02901
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General Information
Symbol
Dmel\Mes2KG02901
Species
D. melanogaster
Name
FlyBase ID
FBal0134393
Feature type
allele
Associated gene
Dmel\Mes2
Associated Insertion(s)
P{SUPor-P}Mes2KG02901
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Zimmermann et al., 2006)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}Mes2KG02901
Cytology
Description

Small deletion that removes a portion of the first exon, including the start codon, and all of the second exon of Mes2.

(Zimmermann et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Mes2KG02901 first instar larvae are sluggish, but do respond to touch. The growth of the mutant larvae is severely impaired compared to heterozygous siblings. Mutant animals arrest development during the L1 stage, and die during the transition to second instar larval stage. Although some larvae survive up to 8 days after egg laying, they do not progress beyond L1 stage. Larvae fail to shed the L1 cuticle completely. This moulting phenotype is not rescued by feeding ecdysone to the larvae. Maternal-zygotic Mes2KG02901 mutants also die as first instar larvae, and display an identical phenotype to zygotic Mes2KG02901 mutants.

      Mes2KG02901 mutant clones generated in glia display no obvious developmental defects in third instar larval brains.

      (Zimmermann et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Mes2KG02901 is rescued by Mes2+t12

      (Zimmermann et al., 2006)
      Comments

      Expression of Mes2+t12 in Mes2KG02901 homozygous mutant animals fully rescues the lethal phenotype, resulting in viable adult flies with no phenotypic defects.

      (Zimmermann et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG11100KG02901
      Mes2KG02901
      mes2KG02901
      (Zimmermann et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)