FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\spisec.UASp
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General Information
Symbol
Dmel\spisec.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0135620
Feature type
allele
Associated gene
Dmel\spi
Associated Insertion(s)
Carried in Construct
P{UASp-spi.sec}
Also Known As
UAS-spi
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Ghiglione et al., 2002)
Progenitor genotype
Carried in construct
P{UASp-spi.sec}
Cytology
Description

UASp regulatory sequences drive expression of a secreted form of spi.

(Ghiglione et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
spi
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Corl et al., 2009)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of spisec.Scer\UAS.P\T under the control of Scer\GAL4tub results in flies with increased resistance to ethanol-induced sedation compared to control flies.

      (Corl et al., 2009)

      Expression of spisec.Scer\UAS.P\T in the germline under the control of Scer\GAL4otu.PR results in dorsalisation of the eggshell in 33% of eggs.

      (Ghiglione et al., 2002)

      Border cell migration is affected when spisec.Scer\UAS.P\T is expressed under the control of either Scer\GAL4slbo.2.6; no border cell migration is seen in most stage 10 egg chambers.

      (Duchek and Rorth, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      spisec.Scer\UAS.P\T
      spisec.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (8)