FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PGRP-LC1
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General Information
Symbol
Dmel\PGRP-LC1
Species
D. melanogaster
Name
FlyBase ID
FBal0137407
Feature type
allele
Associated gene
Dmel\PGRP-LC
Associated Insertion(s)
Carried in Construct
Also Known As
PGRP-LCird7(1)
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Choe et al., 2002)
Progenitor genotype
Cytology
Description

858bp insertion of single copy sequence into PGRP-LC exon 2 which introduces a stop codon.

(Choe et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PGRP-LC1 homozygous adults exhibit a significantly increased mortality after abdominal infection with Erwinia carotovora carotovora bacteria, as compared to controls.

      (Neyen et al., 2016)

      Mutant flies infected with Erwinia carotovora carotovora by septic injury rapidly succumb to the infection.

      (Neyen et al., 2012)

      Blood cells from mutant animals can phagocytose bacteria.

      (Choe et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      PGRP-LC1 is rescued by PGRP-LC+tNa

      (Neyen et al., 2012)
      Comments

      PGRP-LC+tNa (carried either in M{PGRP-LC.PGRP-LF} or in M{PGRP-LC}) rescues the susceptibility of PGRP-LC1 flies to infection with Erwinia carotovora carotovora by septic injury.

      (Neyen et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      PGRP-LC1
      (Snee et al., 2023)
      PGRP-LCird7(1)
      (Neyen et al., 2016, Neyen et al., 2012)
      ird71
      (Choe et al., 2002)
      ΔLCird7(1)
      (Neyen et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)