FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atpαhs.PS
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General Information
Symbol
Dmel\Atpαhs.PS
Species
D. melanogaster
Name
heat shock construct of Sun
FlyBase ID
FBal0138585
Feature type
allele
Associated gene
Dmel\Atpα
Associated Insertion(s)
Carried in Construct
P{hs-Atpα.S}
Key Links
Transgenic product class
synonymous_variant
(Sun et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
synonymous_variant
(Sun et al., 2001)
Mutagen
in vitro construct
(Sun et al., 2001)
Progenitor genotype
Carried in construct
P{hs-Atpα.S}
Cytology
Description

An Hsp70 promoter drives expression of wild-type Atpα with the nucleotide substitution G1177A. This change does not result in any amino acid changes, but results in the formation of an SpeI site at position 1181.

(Sun et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Atpα
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Atpαhs.PS show increased resistance to ouabain in a feeding assay compared to wild-type flies. They show bang sensitive paralysis and reduced open-field locomotor activity.

      (Sun et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Atpαhs.PS partially rescues Atpα2206

      (Sun et al., 2001)
      Comments

      Partially rescues the ouabain sensitivity of Atpα2206 homozygotes. Atpα2206 homozygotes that are also expressing Atpαhs.PS recover more quickly following paralysis (induced by vigorous mechanical stimulation) than Atpα2206 homozygotes which do not carry Atpαhs.PS. The activity defects in a reactive climbing assay that are seen in Atpα2206 homozygotes are rescued if they are also expressing Atpαhs.PS.

      (Sun et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Atpαhs.PS
      Name Synonyms
      heat shock construct of Sun
      (Sun et al., 2001)
      Secondary FlyBase IDs
        References (1)