FlyBase Allele Report: Dmel\drm[unspecified]

General Information

Symbol

Dmel\drm^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0141168

Feature type

allele

Associated gene

Dmel\drm

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic dorsal epidermis

(Hatini et al., 2005)

embryonic foregut

(Johansen et al., 2003)

embryonic hindgut

(Johansen et al., 2003, Green et al., 2002)

embryonic large intestine

(Green et al., 2002)

embryonic proventriculus

(Johansen et al., 2003, Green et al., 2002)

embryonic small intestine

(Green et al., 2002)

hindgut

(Inaki et al., 2024)

keyhole structure

(Johansen et al., 2003)

Detailed Description

Statement

Reference

The 1^o-3^o fates of the dorsal epidermis are replaced with the 4^o fate in mutant embryos.

(Hatini et al., 2005)

In drm^unspecified homozygous embryos the proventriculus fails to form and the hindgut is short and wide, with duplicated boundary cell rows. The foregut fails to form the keyhole structure, as indicated by marker analysis and the lack of a gap in the visceral musculature over this region of the gut, and so remains as a narrow tube.

(Johansen et al., 2003)

The hindgut is wider and shorter than normal in mutant embryos. The small intestine is missing, the cells of the large intestine are columnar (resembling the cells of the immature wild-type hindgut primordium) and the boundary cell rows that run along the length of the large intestine are duplicated. The proventriculus does not fold properly.

(Green et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

drm^unspecified is a non-enhancer of embryonic foregut phenotype of lin^unspecified

(Johansen et al., 2003)

drm^unspecified is a non-enhancer of keyhole structure phenotype of lin^unspecified

(Johansen et al., 2003)

NOT Suppressor of

Statement

Reference

drm^unspecified is a non-suppressor of embryonic foregut phenotype of lin^unspecified

(Johansen et al., 2003)

drm^unspecified is a non-suppressor of keyhole structure phenotype of lin^unspecified

(Johansen et al., 2003)

Other

Statement

Reference

drm^unspecified, lin^unspecified has keyhole structure phenotype

(Johansen et al., 2003)

drm^unspecified, lin^unspecified has embryonic foregut phenotype

(Johansen et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The dorsal cuticle phenotype of drm^unspecified lin^unspecified double mutant embryos is the same as that of lin^unspecified single mutant embryos.

(Hatini et al., 2005)

lin^unspecified; drm^unspecified double homozygous embryos have a foregut phenotype identical to those of lin^unspecified homozygotes (bloated and with an expanded keyhole structure), rather than drm^unspecified homozygotes (narrow and lacking a keyhole structure).

(Johansen et al., 2003)

lin^unspecified drm^unspecified double mutant embryos have the same mutant hindgut and foregut phenotypes as lin^unspecified single mutant embryos.

(Green et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

drm^unspecified is partially rescued by drm^t18.1

(Green et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

drm^unspecified

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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