FB2026_03 , released September 17, 2026
Allele: Dmel\E(tc)1
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General Information
Symbol
Dmel\E(tc)1
Species
D. melanogaster
Name
FlyBase ID
FBal0141839
Feature type
allele
Associated gene
E(tc)
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        E(tc)1 is a dominant mutation that markedly increases the frequency of terminal DNA elongation by gene conversion in terminally deleted chromosomes. E(tc)1 does not significantly influence the frequency of HeT-A and TART-element attachment to the broken chromosome end and does not significantly influence recombination between directly repeated sequences at the end of the truncated chromosome. D.melanogaster lines that carry the E(tc)1 mutation for many generations have telomeres, consisting of HeT-A and TART-elements, that are longer than those found in wild-type lines.

        (Melnikova and Georgiev, 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        E(tc)
        (Melnikova and Georgiev, 2002)
        E(tc)1
        Name Synonyms
        Secondary FlyBase IDs
          References (1)