FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hydK3.5
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General Information
Symbol
Dmel\hydK3.5
Species
D. melanogaster
Name
FlyBase ID
FBal0144235
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    No mutation has been found within the exons or introns of the transcription unit.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    hydK3.5 clones die 2-3 days post generation in larval wing imaginal discs and are removed from the epithelium.

    Homozygous clones in the eye disc induce outgrowths of the wild-type tissue surrounding the clone, although the clones themselves so not persist to adulthood. The clones either form scars in the adult eye or head cuticle at its margin. Premature photoreceptor differentiation is seen in clones in a region just anterior to the morphogenetic furrow, with the ectopic differentiation spreading beyond the borders of the mutant clone into the surrounding wild-type tissue. Rarely, photoreceptor differentiation is seen in clones lying near the anterior margin. Mutant clones in the posterior of the eye disc are generally smaller than similar wild-type clones and contain reduced numbers of photoreceptors. Mutant clones in the eye induced in a Minute background result in pharate adults with greatly reduced eyes. The eyes do appear to contain properly formed hydK3.5 mutant ommatidia.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The phenotype of hydK3.5 clones in the eye disc is partly suppressed if they are also mutant for hhrJ413; ectopic photoreceptors are no longer formed in or around the clone, but some clones still induce overgrowth of wild-type tissue.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (4)