FB2026_02 , released June 18, 2026
Allele: Dmel\RanGAPβTub85D.PK
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General Information
Symbol
Dmel\RanGAPβTub85D.PK
Species
D. melanogaster
Name
βTub85D promoter construct of Kusano
FlyBase ID
FBal0144578
Feature type
allele
Associated gene
Dmel\RanGAP
Associated Insertion(s)
Carried in Construct
P{βTub85D-RanGAP.K}
Key Links
Transgenic product class
wild_type
(Kusano et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kusano et al., 2002)
Mutagen
in vitro construct
(Kusano et al., 2002)
Progenitor genotype
Carried in construct
P{βTub85D-RanGAP.K}
Cytology
Description

The ORF of wild-type RanGAP is driven by a testis specific promoter (βTub85D promoter).

(Kusano et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
βTub85D
Encoded product / tool
RanGAP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      RanGAPβTub85D.PK causes very strong segregation distortion in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion does not occur if the target homolog chromosome carries Rspi in place of Rspss. Overexpression of RanGAPβTub85D.PK does not cause segregation distortion in the presence of the "SD-5[R16]" chromosome (which carries a strong suppressor of SD in addition to RanGAPSd, E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. RanβTub85D.PK and Rcc1βTub85D.PK can both suppress the segregation distortion phenotype caused by RanGAPβTub85D.PK in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss.

      (Kusano et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      RanGAPβTub85D.PK
      RanGapβTub85D.PK
      SdβTub85D.PK
      Name Synonyms
      βTub85D promoter construct of Kusano
      (Kusano et al., 2002)
      Secondary FlyBase IDs
        References (1)