FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pummilord-1
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General Information
Symbol
Dmel\pummilord-1
Species
D. melanogaster
Name
FlyBase ID
FBal0146876
Feature type
allele
Associated gene
Dmel\pum
Associated Insertion(s)
P{lacZ}pummilord-1
Carried in Construct
Also Known As
milord-1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Dubnau et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{lacZ}pummilord-1
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacZ}
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous pummilord-1 mutants show increased sensitivity to ethanol vapor compared with controls. pummilord-1 mutant flies also show reduced tolerance to ethanol. Whereas control flies exhibit a reduced behavioural response following pre-exposure to ethanol in comparison with humidified air, pummilord-1 mutant flies exposed to either ethanol or air produce a similar response.

      (Berger et al., 2008)

      In memory tests, mutants perform at % of wild-type after a single training session, at % after spaced training.

      (Dubnau et al., 2003)

      Homozygotes exhibit severe defects in one-day memory after spaced training. Heterozygotes exhibit a weaker phenotype.

      (Dubnau et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      pumFC8

      (Dubnau et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Etymology: Given the name "milord", after one of Pavlov's dogs.

      (Dubnau et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      E0469
      (Berger et al., 2008, Dubnau et al., 2003)
      milord-1
      (Berger et al., 2008)
      pummilord-1
      pummilord
      (Greenspan, 2003)
      Name Synonyms
      milord-1
      (Dubnau et al., 2003, Dubnau et al., 2003)
      Secondary FlyBase IDs
        References (4)