FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\p53S4A.UAS
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General Information
Symbol
Dmel\p53S4A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0146956
Feature type
allele
Associated gene
Dmel\p53
Associated Insertion(s)
Carried in Construct
P{UAS-p53.S4A}
Key Links
Transgenic product class
missense_variant
(Peters et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Peters et al., 2002)
Mutagen
in vitro construct
(Peters et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-p53.S4A}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of p53 (carries the amino acid replacement S4A).

(Peters et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
p53
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of p53S4A.Scer\UAS under the control of Scer\GAL4GMR.PF results in a small eye phenotype.

      (Peters et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PF, p53S4A.UAS has visible phenotype, non-suppressible by Scer\GAL4GMR.PF/lokD303A.UAS

      (Peters et al., 2002)

      Scer\GAL4GMR.PF, p53S4A.UAS has visible phenotype, non-suppressible by Scer\GAL4GMR.PF/lokUAS.cPa

      (Peters et al., 2002)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PF, p53S4A.UAS has eye phenotype, non-enhanceable by Scer\GAL4GMR.PF/lokD303A.UAS

      (Peters et al., 2002)

      Scer\GAL4GMR.PF, p53S4A.UAS has eye phenotype, non-enhanceable by Scer\GAL4GMR.PF/lokUAS.cPa

      (Peters et al., 2002)
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PF, p53S4A.UAS has eye phenotype, non-suppressible by Scer\GAL4GMR.PF/lokD303A.UAS

      (Peters et al., 2002)

      Scer\GAL4GMR.PF, p53S4A.UAS has eye phenotype, non-suppressible by Scer\GAL4GMR.PF/lokUAS.cPa

      (Peters et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye phenotype caused by expression of p53S4A.Scer\UAS under the control of Scer\GAL4GMR.PF is not altered by coexpression of lokScer\UAS.cPa or lokD303A.Scer\UAS.

      (Peters et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      p53S4A.Scer\UAS
      p53S4A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)