FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dikarE3145
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General Information
Symbol
Dmel\dikarE3145
Species
D. melanogaster
Name
FlyBase ID
FBal0147208
Feature type
allele
Associated gene
Dmel\dikar
Associated Insertion(s)
P{lacZ}dikarE3145
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Dubnau et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{lacZ}dikarE3145
Cytology
Description

Insertion in the last few base pairs of the exon 1B extension, 72 bp downstream from the end of exon 1B, and 127 bp upstream from the P{SUPor-P}dikarKG00884 insertion.

(Keuling et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{lacZ}
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous dikarE3145 mutant flies do not show any change in sensitivity to ethanol vapor compared to controls.

      (Berger et al., 2008)

      Homozygotes and heterozygotes (to a lesser extent) show deficits in 1-day memory after spaced training, however complementation analysis suggests that this memory phenotype is most likely due a second-site mutation in the background of the P{lacZ}dikarE3145 insertion stock.

      (Keuling et al., 2007)

      In memory tests, mutants perform at 95% of wild-type after a single training session, at 53% after spaced training. FlyBase curator comment: complementation analysis in FBrf0201526 indicates that the memory deficit seen in P{lacZ}dikarE3145 mutants is probably not caused by the insertion in the dikar gene, but is most likely caused by a second-site mutation.

      (Dubnau et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      dikar3/dikarE3145 and dikar5/dikarE3145 animals do not show defects in long term memory.

      (Keuling et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Complementation tests between P{lacZ}dikarE3145 and the dikar3 and dikar5 alleles suggest that the long term memory deficit seen in P{lacZ}dikarE3145 mutants is probably not caused by the insertion in the dikar gene, but is most likely caused by a second-site mutation.

      (Keuling et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      E3145
      (Berger et al., 2008, Dubnau et al., 2003)
      dikar
      (Berger et al., 2008)
      dikar1
      dikarE3145
      Name Synonyms
      Secondary FlyBase IDs
        References (3)