FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nup98-96E53.1
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General Information
Symbol
Dmel\Nup98-96E53.1
Species
D. melanogaster
Name
FlyBase ID
FBal0147719
Feature type
allele
Associated gene
Dmel\Nup98-96
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: G3063A.

    (Presgraves et al., 2003)

    Amino acid replacement: W1021term.

    (Presgraves et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:23,777,963..23,777,963 [-]
    Nucleotide change:

    G23777963A

    Reported nucleotide change:

    G3065A

    Amino acid change:

    W1021term | Nup98-96-PA; W1021term | Nup98-96-PC; W1021term | Nup98-96-PD

    Reported amino acid change:

    W1021term

    (Presgraves et al., 2003)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Hybrid males that are heterozygous Nup98E53.1/D.simulans and carried the D.melanogaster X are inviable; by contrast, hybrid males that have an identical genotype and carries the D.simulans X chromosome are viable.

        (Presgraves et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        Nup98E53.1 reduces the viability of Hmr2-rescued hybrid males derived from of a cross of D.melanogaster females to D.simulans males or from a cross of D.melanogaster females to D.sechellia males. Nup98E53.1 has no effect on the viability of Hmr2-rescued hybrid males derived from of a cross of D.melanogaster females to D.mauritiana males.

        Nup98E53.1 has no effect on viability of hybrid females derived from of a cross of D.melanogaster females to D.simulans males.

        The ability of HmrDf to rescue the viability of hybrid males derived from of a cross of D.melanogaster females to D.simulans males or from a cross of D.melanogaster females to D.sechellia males is completely suppressed by Nup98E53.1.

        The ability of HmrDf to rescue the viability of hybrid males derived from of a cross of D.melanogaster females to D.mauritiana males is not affected by Nup98E53.1.

        (Barbash, 2007)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        Nup96-
        (Barbash, 2007)
        Nup98-96E53.1
        Nup98E53.1
        (Barbash, 2007)
        l(3)95BCdE53.1
        (Presgraves et al., 2003)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)