FlyBase Allele Report: Dmel\ApepP[EY02585]

General Information

Symbol

Dmel\ApepP^EY02585

Species

D. melanogaster

Name

FlyBase ID

FBal0148478

Feature type

allele

Associated gene

Dmel\ApepP

Associated Insertion(s)

P{EPgy2}ApepP^EY02585

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}ApepP^EY02585

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:16,910,414..16,910,414 [-]

(Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | late embryonic stage

(Blundon et al., 2016)

decreased body size | late embryonic stage (with ApepP^MI01970)

(Blundon et al., 2016)

increased mortality during development

(Blundon et al., 2016)

majority die during embryonic stage | maternal effect

(Blundon et al., 2016)

some die during embryonic stage (with ApepP^MI01970)

(Blundon et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

The majority of ApepP^EY02585 homozygous embryos from ApepP^EY02585 homozygous mothers die during the embryonic stage, these and ApepP^EY02585/ApepP^MI01970 embryos exhibit cuticle defects, including head defects, fusion of the first and second denticle rows, denticle loss and body holes, as well as a reduction in body length; embryonic lethality is reduced in the transheterozygotes. ApepP^EY02585 homozygous progeny from ApepP^EY02585 heterozygous parents survive to adulthood, but at a lower than expected mendelian ratio.

(Blundon et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ApepP^EY02585 has increased mortality during development phenotype, enhanceable by Apc2^g10/Apc2^g10

(Blundon et al., 2016)

NOT Enhanced by

Statement

Reference

ApepP^EY02585 has majority die during embryonic stage | maternal effect phenotype, non-enhanceable by Apc2^g10/Apc2[+]

(Blundon et al., 2016)

NOT suppressed by

Statement

Reference

ApepP^EY02585 has majority die during embryonic stage | maternal effect phenotype, non-suppressible by Apc2^g10/Apc2[+]

(Blundon et al., 2016)

Enhancer of

Statement

Reference

ApepP[+]/ApepP^EY02585 is an enhancer of increased mortality during development phenotype of Apc2^g10

(Blundon et al., 2016)

ApepP^EY02585/ApepP^EY02585 is an enhancer of increased mortality during development phenotype of Apc2^g10

(Blundon et al., 2016)

Other

Statement

Reference

Apc2^g10, ApepP^EY02585 has lethal - all die before end of P-stage phenotype

(Blundon et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

ApepP^EY02585 has embryonic head phenotype, enhanceable by Apc2^g10/Apc2[+]

(Blundon et al., 2016)

Suppressed by

Statement

Reference

ApepP^EY02585 has embryonic/first instar larval cuticle phenotype, suppressible | partially by Apc2^g10/Apc2[+]

(Blundon et al., 2016)

ApepP^EY02585 has denticle row | late embryonic stage phenotype, suppressible | partially by Apc2^g10/Apc2[+]

(Blundon et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

ApepP^EY02585 homozygous or heterozygous progeny from ApepP^EY02585 heterozygous parents do not reach adulthood when also homozygous for Apc2^g10, inherited from heterozygous parents.

(Blundon et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

15423