FB2026_02 , released June 18, 2026
Allele: Dmel\hhN.UAS.cGa
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General Information
Symbol
Dmel\hhN.UAS.cGa
Species
D. melanogaster
Name
FlyBase ID
FBal0150433
Feature type
allele
Associated gene
Dmel\hh
Associated Insertion(s)
Carried in Construct
P{UAS-hh.N.G}
Key Links
Transgenic product class
stop_gained
(Gallet et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
stop_gained
(Gallet et al., 2003)
Mutagen
in vitro construct
(Gallet et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-hh.N.G}
Cytology
Description

UASt regulatory sequences drive expression of a truncated hh open reading frame (a stop codon has been introduced at codon 258). This is expected to result in a protein in which addition of cholesterol to the C-terminal end of the protein does not occur, while palmitoylation can still occur at the N-terminal end.

(Gallet et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
hh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hhN.Scer\UAS.cGa expressing cells display strong punctate labeling on the plasma membrane.

      Clones of peripodial cells expressing hhN.Scer\UAS.cGa under the control of Scer\GAL4en-e16E induce significant outgrowth of the anterior compartment of the wing imaginal disc.

      (Gallet et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Clones of peripodial cells expressing both hhN.Scer\UAS.cGa and dispScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4en-e16E induce significant outgrowth of the anterior compartment of the wing imaginal disc.

      (Gallet et al., 2006)

      Expression of hhN.Scer\UAS.cGa with Scer\GAL4en-e16E in dispS037707 germ-line clone embryos doesn't rescue naked cuticle formation, but does increase denticle diversity in the ventral cuticle: row 3,4 and 5 type denticles are all present: denticles type 3 and 4 cover each segment, whereas type 5 denticles have almost totally disappeared.

      (Gallet et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      hhN.UAS.cGa/Scer\GAL4unspecified rescues hhAC

      (Gallet et al., 2006)
      Partially rescues

      hhN.UAS.cGa/Scer\GAL469B partially rescues hhAC

      (Gallet et al., 2003)
      Comments

      Expression of hhN.Scer\UAS.cGa, under the control of Scer\GAL4unspecified rescues the hhAC phenotype.

      (Gallet et al., 2006)

      Naked cuticle formation in hhAC homozygous embryonic cuticle is partially rescued by hhN.Scer\UAS.T:Ivir\HA1; Scer\GAL469B (some denticle belts are fused at the midline). The denticle belts formed consist of (A-P) a single row 1 type followed by a number of row 2, sometimes followed by a row 1.

      (Gallet et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hhN.Scer\UAS.cGa
      hhN.UAS.cGa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)