FB2026_02 , released June 18, 2026
Allele: Dmel\Rst(2)DDT-WIS1WIS1
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General Information
Symbol
Dmel\Rst(2)DDT-WIS1WIS1
Species
D. melanogaster
Name
FlyBase ID
FBal0150647
Feature type
allele
Associated gene
Rst(2)DDT-WIS1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Rst(2)DDT-WIS1WIS1 adults show increased resistance to DDT compared to Canton-S flies. Rst(2)DDT-WIS1WIS1 larvae show increased resistance to imidacloprid and to malathion compared to Canton-S larvae.

        (Le Goff et al., 2003)

        Rst(2)DDT-WIS1WIS1 animals show increased resistance to DDT and imidacloprid relative to Canton-S animals.

        (Daborn et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Derived from a field collection in Wisconsin, USA and then repeatedly selected with DDT with no genetic intervention.

        (Le Goff et al., 2003)
        Comments
        Comments

        Cyp6g1 and "Cyp12d1" (Cyp12d1-p and Cyp12d1-d) are overtranscribed in Rst(2)DDT-WIS1WIS1 animals compared to in Canton-S animals.

        (Le Goff et al., 2003)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        Rst(2)DDT-WIS1WIS1
        Rst(2)DDTWis1
        (Daborn et al., 2001)
        WIS1
        (Le Goff et al., 2003)
        Name Synonyms
        Wisconsin-1
        (Le Goff et al., 2003)
        Secondary FlyBase IDs
          References (2)