D.simulans females carrying Dsim\Shfr^TelAviv mated to D.melanogaster males produce progenies with males and 20% or more females, indicating female hybrid rescue (the female progeny of D.simulans females mated to D.melanogaster males usually die as embryos). The female hybrid rescue seen in the progeny of D.simulans Dsim\Shfr^TelAviv females mated to D.melanogaster males is temperature dependent, with a larger rescue success as temperature decreases. Dsim\Shfr^TelAviv appears to be dominant and to act zygotically in female hybrid rescue. Dsim\Shfr^TelAviv does not rescue the viability of hybrid males derived from a cross between D.simulans males and D.melanogaster females.