FlyBase Allele Report: Dmel\mtrm[exc13]

General Information

Symbol

Dmel\mtrm^exc13

Species

D. melanogaster

Name

FlyBase ID

FBal0151716

Feature type

allele

Associated gene

Dmel\mtrm

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Harris et al., 2003)

Progenitor genotype

P{SUPor-P}Exo70^KG08051

(Harris et al., 2003)

Caused by aberration

Df(3L)KG08051-exc13

Cytology

Description

Excision of the P{SUPor-P}Exo70^KG08051 insertion, which has resulted in a large deletion of material upstream of the site of the insertion, including the first 3 exons of Exo70.

(Harris et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | dominant

(Xiang et al., 2007, Harris et al., 2003)

Phenotype Manifest In

oocyte nucleus | oogenesis stage S12

(Xiang et al., 2007)

Detailed Description

Statement

Reference

Heterozygous females show precocious nuclear envelope breakdown in stage 12 oocytes.

(Xiang et al., 2007)

Heterozygosity for mtrm^exc13 results in elevated X (49.0%) and fourth (29.0%) chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females compared to controls. The level of X chromosome nondisjunction in heterozygous mtrm^exc13 females carrying two normal sequence X chromosomes is only 3.1%, while the frequency of fourth chromosome nondisjunction in these females is 31.0%.

(Harris et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mtrm^exc13 has abnormal meiotic cell cycle phenotype, suppressible by polo^KG03033

(Xiang et al., 2007)

Other

Statement

Reference

Exo70^exc13, mtrm^exc13 has partially lethal - majority die | recessive phenotype

(Harris et al., 2003)

Exo70^exc13, mtrm^exc13 has partially lethal - majority die phenotype

(Harris et al., 2003)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

607084

y¹ w^*; Df(3L)KG08051-exc13, mtrm^exc13/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Associated with: exo70^exc13.

(Harris et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mtrm^exc13

(Xiang et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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