FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-4199B
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General Information
Symbol
Dmel\mei-4199B
Species
D. melanogaster
Name
FlyBase ID
FBal0151734
Feature type
allele
Associated gene
Dmel\mei-41
Associated Insertion(s)
P{5'3'}mei-4199B
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Laurencon et al., 2003)
Progenitor genotype
mei-41RT1
(Laurencon et al., 2003)
Associated Insertion(s)
P{5'3'}mei-4199B
Cytology
Description

Imprecise excision of the P-element, deleting most of the P-element sequence; 13bp of 5' inverted repeat and 17bp of the 3' inverted repeat remain, separated by the nucleotides CA. In addition, the 8bp target site duplication is present. This arrangement creates a stop codon downstream of the insertion site, and is predicted to encode a truncated protein of 340 amino acids.

(Laurencon et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
X:16,393,366..16,393,367 [+]
Inserted_sequence:

CATGATGAAATAACATATGTTATTTCATCATGGTTCATAC

Comment:

The P{}mei-41RT1 insertion is deleted in the mei-4199B strain leaving 40bp of mostly inverted repeat sequence inserted between the reported bases. This leads to a frameshift and early translation termination.

(Laurencon et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes are sensitive to methyl methanesulfonate compared to wild-type animals.

      (Laurencon et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      99B
      (Laurencon et al., 2003)
      mei-4199B
      Name Synonyms
      Secondary FlyBase IDs
        References (1)