FB2026_02 , released June 18, 2026
Allele: Dmel\lunaRNAi.UAS
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General Information
Symbol
Dmel\lunaRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0151739
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of two copies of a 520bp sequence of the 5' portion of a luna cDNA, with the two copies arranged in a head-to-head configuration with an intervening 80-bp linker.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

About half of embryos expressing lunadsRNA.Scer\UAS under the control of Scer\GAL4da.G32 die prior to gastrulation with a characteristic phenotype of numerous vacuoles reminiscent of the lunar surface. Surviving embryos die at the third larval instar or early pupal stage showing black necrotic plaques. Expression of lunadsRNA.Scer\UAS under the control of Scer\GAL4GMR.PF results in a rough eye phenotype characterised by the loss of sensory bristles. Irregular and fused ommatidia and duplicated bristles are sometimes seen. Fewer photoreceptors than normal are present and pigment cells are disorganised. Large, dark vacuoles suggestive of cell death are seen scattered between rhabdomeres and pigment cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
lunaRNAi.UAS
lunadsRNA.Scer\UAS
lunadsRNA.UAS
lunadsRNA.cDa
Name Synonyms
Secondary FlyBase IDs
    References (2)