FB2026_02 , released June 18, 2026
Allele: Dmel\GatA112
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General Information
Symbol
Dmel\GatA112
Species
D. melanogaster
Name
FlyBase ID
FBal0152102
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
112-38
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W154term.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G19028178A

    Amino acid change:

    W154term | GatA-PA

    Reported amino acid change:

    W154term

    Comment:

    G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation

    (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base

    on reported amino acid change.

    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    gatA112/Df(3R)Cha7 larvae do not show any obvious patterning defects, but they grow more slowly than their wild-type siblings. By 3-4 days after egg laying (AEL), the larvae are smaller than controls, and by 5 days after AEL some of the mutant larvae are dead and the living larvae are obviously smaller than controls. The mutant larvae do not pupariate by the end of the fifth day AEL (in contrast to controls) but continue to forage actively on the surface of the food, rarely burrowing into the food and some of them live 9 days or longer as larvae. On day 5 AEL only 76% of the mutant larvae are third instar larvae (the remainder are second instar larvae), in contrast to control larvae which are all third instar larvae by this time.

    The imaginal discs and brains of 5-day old gatA112/Df(3R)Cha7 larvae are much smaller than those of control larvae of the same age. By 3-4 days AEL, the salivary glands of the mutant larvae are smaller and contain less DNA than those of control siblings at 3-4 days, with this difference being even more dramatic at 5 days AEL.

    Homozygous clones in the eye result in small and misshapen eyes which have various differentiation defects, including cuticle scars and ectopic bristles.

    Homozygous clones can be recovered in the eye. Females containing homozygous germ-line clones show defects in early oogenesis. The mutant egg chambers contain underreplicated nurse cells whose nuclei retain polytene morphology beyond stage 5. The karyosomes are fragmented or stringy. This allele has a strong effect on the nurse cell nuclei.

    External Data
    Interactions
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    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer

    Selected as: a mutation that results in a failure to produce eggs when females carry homozygous germ-line clones.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    GatA112
    benedict112-38
    gatA112-38
    Name Synonyms
    Secondary FlyBase IDs
      References (2)