FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sce33M2
Open Close
General Information
Symbol
Dmel\Sce33M2
Species
D. melanogaster
Name
FlyBase ID
FBal0152227
Feature type
allele
Associated gene
Dmel\Sce
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(de Ayala Alonso et al., 2007, Fritsch et al., 2003)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T. Amino acid replacement: R65C.

(Fritsch et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,681,723..27,681,723 [-]
Nucleotide change:

C27681723T

Reported nucleotide change:

C?T

Amino acid change:

R65C | Sce-PA

Reported amino acid change:

R65C

(Fritsch et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Luo-Schoch-Yamamoto syndrome
      CEC with SceKO
      (Luo et al., 2021)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos derived from homozygous female germ line clones show transformation of thoracic denticle belts to those with abdominal character and head involution is incomplete. Paternally rescued Sce33M2/+ animals derived from homozygous female germ line clones develop into viable adult flies.

      (Fritsch et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Sce1

      (Fritsch et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sce33M2
      (Luo et al., 2021, Dardalhon-Cuménal et al., 2018, Gutiérrez et al., 2012, de Ayala Alonso et al., 2007)
      Sce33m2
      (Li et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)