FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Egfract.B.UAS
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General Information
Symbol
Dmel\Egfract.B.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0152530
Feature type
allele
Associated gene
Dmel\Egfr
Associated Insertion(s)
Carried in Construct
P{UAS-Egfr.act.B}
Also Known As
UAS-EGFRAct
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Chang et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Egfr.act.B}
Cytology
Description

UAS drives expression of an activated form of Egfr.

(Chang et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Egfr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing Egfract.B.Scer\UAS under the control of Scer\GAL4how-24B show an increase in the number of dorsal, dorsolateral and lateral adult muscle precursor cells compared to wild type. The number of ventral adult muscle precursor cells is unaffected in these embryos.

      (Figeac et al., 2010)

      In stage 16 Egfract.B.Scer\UAS; Scer\GAL4en-e16E embryos, there are increased numbers of oenocytes per cluster. The number of oenocytes per cluster follows a multi-modal distribution, with peaks corresponding to multiples of 3 (12, 15, 18 and 21) suggesting that additional rounds of delamination, generally of 3 oeoncytes per round as in wild-type, are occurring. This multi-modal distribution and increased numbers of per cluster are partially suppressed by Egfrf2/+.

      (Brodu et al., 2004)

      When Egfract.B.Scer\UAS is driven by Scer\GAL4da.G32 or Scer\GAL4so-GAL4 the resulting phenotype is cyclopia in the embryonic head.

      (Chang et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In stage 16 Egfract.B.Scer\UAS; Scer\GAL4en-e16E embryos, there are increased numbers of oenocytes per cluster. The number of oenocytes per cluster follows a multi-modal distribution, with peaks corresponding to multiples of 3 (12, 15, 18 and 21) suggesting that additional rounds of delamination, generally of 3 oeoncytes per round as in wild-type, are occurring. This multi-modal distribution and increased numbers of per cluster are partially suppressed by abd-AM1/abd-AM1.

      (Brodu et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Egfract.B.Scer\UAS
      Egfract.B.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)