FlyBase Allele Report: Dmel\okr[782]

General Information

Symbol

Dmel\okr⁷⁸²

Species

D. melanogaster

Name

FlyBase ID

FBal0154812

Feature type

allele

Associated gene

Dmel\okr

Associated Insertion(s)

Carried in Construct

Also Known As

okr^Z0682

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

X ray

(Gorski et al., 2003)

ethyl methanesulfonate

(Bhagat et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: T660I.

(Bhagat et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,990,499..2,990,499 [-]

Nucleotide change:

C2990499T

Reported nucleotide change:

C?T

Amino acid change:

T660I | okr-PA

Reported amino acid change:

T660I

(Bhagat et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Bhagat et al., 2004, Jang et al., 2003)

female semi-fertile

(Bhagat et al., 2004)

fertile

(Jang et al., 2003)

radiation sensitive | embryonic stage | rescuable maternal effect (with Df(2L)JS17)

(Gorski et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

okr⁷⁸²/okr⁷⁸² females exhibit reduced fertility, and female meioses show a significant increase in X chromosome non-disjunction, a decrease in crossover frequency along most of the X and 3rd chromosomes, but an increase in crossover frequency in some of the regions close to the centromere. Crossover frequency of chromosome 2 is decreased.

(Bhagat et al., 2004)

When exposed to X-rays during the first 8 hours of embryonic development, the ratio of Df(2L)JS17/okr^17-11 to okr^17-11/+ flies in the offspring of Df(2L)JS17/okr^17-11 females decreases with increasing x-ray dosage (0-15 Gy at about 1 Gy/min). In contrast, the ratio of Df(2L)JS17/okr^17-11 to okr^17-11/+ flies in the offspring of Df(2L)JS17/+ females does not decrease with dosage. At a dose of 9 Gy, nearly a fourfold difference in sensitivity is seen between the Df(2L)JS17/okr^17-11 offspring from okr^17-11 homozygous females in comparison to the offspring from Df(2L)JS17/+ females. Among 8-24 or 24-48 hour-old embryos and larvae, no difference in sensitivity is seen between Df(2L)JS17/okr^17-11 offspring from okr^17-11 homozygous mothers and those from Df(2L)JS17/+.

(Gorski et al., 2003)

okr⁷⁸² mutants exhibit a reduction in meiotic crossing over (to approximately 30% that of wild-type).

okr⁷⁸² mutants are fertile.

(Jang et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

okr⁷⁸² has abnormal meiotic cell cycle phenotype, enhanceable by c(2)M^Z0810/c(2)M^Z0810

(Bhagat et al., 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

okr⁷⁸²/okr⁷⁸², c(2)M^Z0810/c(2)M^Z0810 double mutant female meioses exhibit reduced crossover frequency along most of the X chromosome, but significantly higher crossover frequency near the centromere, as compared to either single mutant.

(Bhagat et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Rad54⁷⁸²

(Gorski et al., 2003)

okr²⁰⁶⁸²

(Gorski et al., 2003)

okr⁷⁸²

okr^Z0682

(Bhagat et al., 2004, Jang et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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