FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-9RT3
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General Information
Symbol
Dmel\mei-9RT3
Species
D. melanogaster
Name
FlyBase ID
FBal0154956
Feature type
allele
Associated gene
Dmel\mei-9
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Yildiz et al., 2004)
Progenitor genotype
Cytology
Description

Insertion of a T residue just after the nuclease domain, resulting in a frameshift. The predicted protein contains mei-9 residues 1-742 followed by 50 novel residues.

(Yildiz et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
X:4,315,383..4,315,383 [-]
Comment:

Insertion of 1bp (T) just after the nuclease domain, resulting in a frameshift. The predicted protein contains mei-9 residues 1-785 followed by 50 novel residues. Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

Inserted_sequence:

T

(Yildiz et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mei-9RT3/mei-9A2 females show 22% X chromosome nondisjunction, compared to 0.33% in wild-type females. mei-9RT1/mei-9RT3 females show a severe decrease in the level of crossing over along the left arm of chromosome 2 compared to wild type. mei-9RT3/mei-9A2 larvae are hypersensitive to ultraviolet light and nitrogen mustard.

      (Yildiz et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Alleles mei-9RT2 and mei-9RT3 contain the same molecular lesion.

      (Yildiz et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-9RT3
      Name Synonyms
      Secondary FlyBase IDs
        References (1)