FB2026_03 , released September 17, 2026
Allele: Dmel\mei(3)M201
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General Information
Symbol
Dmel\mei(3)M201
Species
D. melanogaster
Name
FlyBase ID
FBal0154958
Feature type
allele
Associated gene
mei(3)M20
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Hirai et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      C(1;Y)6/Dp(1;f)YP223 males that are homozygous for mei(3)M201 show a high frequency of non-disjunction of the sex chromosomes (41.6%) and fourth chromosomes (47.6%). Homozygous XY males show a high frequency of non-disjunction of the sex chromosomes (39.2%) and fourth chromosomes (47.4%). Mutants also show a high frequency of nondisjunction of the 2nd and 3rd chromosomes. Analysis of the progeny of homozygous males mated to compound-X females indicates that mei(3)M201 predominantly disrupts meiosis I, although some meiosis II nondisjunctional sperm are also produced. Although homologous chromosomes are paired in the primary spermatocytes of homozygous males, sister centromeres are prematurely separated as early as prometaphase I. Homozygous females mated to wild-type males lay a large number of eggs which are morphologically normal, but only about 5% of the eggs hatch and only 51.0% of the eggs develop beyond the syncytial blastoderm stage. X chromosome nondisjunction in homozygous females is about 40.0%.

      (Hirai et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      C(1;Y)6/Dp(1;f)YP223 males that are also mei(3)M191/mei(3)M201 show a high frequency of non-disjunction of the sex chromosomes (43.8%) and fourth chromosomes (55.2%).

      (Hirai et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      "mei(3)M191" and "mei(3)M201" were recovered from the same Ishigaki natural population and most probably represent two independent isolates of the same mutation.

      (Hirai et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mei(3)M20
      (Hirai et al., 2004)
      mei(3)M201
      Name Synonyms
      Secondary FlyBase IDs
        References (1)