FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RhoGAP68FEY05896
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General Information
Symbol
Dmel\RhoGAP68FEY05896
Species
D. melanogaster
Name
FlyBase ID
FBal0155968
Feature type
allele
Associated gene
Dmel\RhoGAP68F
Associated Insertion(s)
P{EPgy2}RhoGAP68FEY05896
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}RhoGAP68FEY05896
Cytology
Description

Insertion in the open reading frame.

(Sanny et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Surviving homozygous adults show no obvious mutant phenotypes.

      When RhoGAP68FEY05896 homozygous females are mated to Df(3L)vin5/TM3 males, 22% of the resulting embryos die with holes in the ventral and/or dorsal cuticle, 35% fail to secrete cuticle and the remaining 43% develop wild-type cuticles.

      When Df(3L)vin5/TM3 females are mated to RhoGAP68FEY05896 homozygous males, 3.2% of the resulting embryos have holes in the cuticle and 8% fail to form a cuticle.

      When RhoGAP68FEY05896 homozygous females are mated to wild-type males, 5.8% of the resulting embryos have holes in the cuticle and 17.3% fail to form cuticle.

      (Sanny et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When RhoGAP68FEY05896 homozygous females that are also heterozygous for Rho1k02107rev5 are mated to Df(3L)vin5/TM3 males, there is a modest but significant increase in the proportion of the resulting embryos that form wild-type cuticle (49%) and fewer embryos showing holes in the cuticle (10%) compared to the progeny RhoGAP68FEY05896 homozygous females mated to Df(3L)vin5/TM3 males. However, there is also an increase in the frequency of failures to form cuticle (41%).

      (Sanny et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RhoGAP68FEY05896
      (Sanny et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)