FB2026_02 , released June 18, 2026
Allele: Dmel\InRK414P.GMR
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General Information
Symbol
Dmel\InRK414P.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0156358
Feature type
allele
Associated gene
Dmel\InR
Associated Insertion(s)
Carried in Construct
P{GMR-InR.K414P}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Parks, 2020.2.14)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Parks, 2020.2.14)
Mutagen
in vitro construct
(Parks, 2020.2.14)
Progenitor genotype
Carried in construct
P{GMR-InR.K414P}
Cytology
Description

GMR regulatory sequences drive expression of InR that carries an K418P amino acid replacement (numbering using GenBank submission gb|AAC47458). This change corresponds to K414P in the current release of the Drosophila genome (release 6). The change is meant to mimic the R113P change in Longo et al., 1993 (PMID:8419945) (R113P is called R86P in the paper). (Revision of data in FBrf0178856, where it was incorrectly annotated as carrying a R418P change).

(Parks, 2020.2.14)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
InR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,579,144..21,579,145 [-]
Nucleotide change:

AA21579145CC

Amino acid change:

K414P | InR-PA; K414P | InR-PB; K414P | InR-PC; K414P | InR-PD

Reported amino acid change:

K414P

Comment:

Analogous R113P mutation in human INSR implicated in Donohue syndrome; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Parks, 2020.2.14)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Parks, 2004.5.12)
      INSR:p.Arg113Pro
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      INSR:p.Arg86Pro
      Associated human disease model(s)
      External database links
      ClinVar: INSR_14703
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      InRK414P.GMR
      InRR418P.GMR
      Name Synonyms
      Secondary FlyBase IDs
        References (3)