K414P | InR-PA; K414P | InR-PB; K414P | InR-PC; K414P | InR-PD
Analogous R113P mutation in human INSR implicated in Donohue syndrome; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.
GMR regulatory sequences drive expression of InR that carries an K418P amino acid replacement (numbering using GenBank submission gb|AAC47458). This change corresponds to K414P in the current release of the Drosophila genome (release 6). The change is meant to mimic the R113P change in Longo et al., 1993 (PMID:8419945) (R113P is called R86P in the paper). (Revision of data in FBrf0178856, where it was incorrectly annotated as carrying a R418P change).