FlyBase Allele Report: Dmel\SREBP[UAS.Exel]

General Information

Symbol

Dmel\SREBP^UAS.Exel

Species

D. melanogaster

Name

FlyBase ID

FBal0156411

Feature type

allele

Associated gene

Dmel\SREBP

Associated Insertion(s)

Carried in Construct

P{UAS-SREBP.Exel}

Also Known As

UAS-SREBP^WT, UAS-SREBP

Key Links

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{UAS-SREBP.Exel}

Cytology

Description

UAS regulatory sequences drive expression of full-length SREBP.

(Porstmann et al., 2008)

Wild type SREBP coding sequence was cloned into P{Express-UAS}; expression is governed by UAS regulatory sequences.

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

SREBP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of heart conduction disease

CEA with SREBP^Cdel.UAS

(Lim et al., 2011)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing SREBP^UAS.Exel under the control of Scer\GAL4^GMR.PFa or Scer\GAL4^ninaE.PT display normal synaptic vesicle staining (CSP staining as proxy) and stereotyped cartridge structures.

(Tsai et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

SREBP^UAS.Exel/Scer\GAL4^{DIP-γ-MI03222-GAL4} is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of mTor^ΔP

(Luo et al., 2020)

NOT Suppressor of

Statement

Reference

SREBP^UAS.Exel/Scer\GAL4^GMR.PFa is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive | conditional phenotype of Pect^omb593

(Tsai et al., 2019)

SREBP^UAS.Exel, Scer\GAL4^GMR.PFa is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^GMR.PFa, eas^KK102681

(Tsai et al., 2019)

SREBP^UAS.Exel, Scer\GAL4^GMR.PFa is a non-suppressor of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PFa, eas^KK102681

(Tsai et al., 2019)

Other

Statement

Reference

Pi3K92E^UAS.Tag:MYC, SREBP^UAS.Exel, Scer\GAL4^Bx-MS1096 has visible phenotype

(Porstmann et al., 2008)

Phenotype Manifest In

Suppressor of

Statement

Reference

SREBP^UAS.Exel/Scer\GAL4^{DIP-γ-MI03222-GAL4} is a suppressor of distal medullary amacrine neuron Dm8a | somatic clone | adult stage phenotype of mTor^ΔP

(Luo et al., 2020)

SREBP^UAS.Exel/Scer\GAL4^{DIP-γ-MI03222-GAL4} is a suppressor of dendrite | somatic clone | adult stage phenotype of mTor^ΔP

(Luo et al., 2020)

NOT Suppressor of

Statement

Reference

SREBP^UAS.Exel/Scer\GAL4^GMR.PFa is a non-suppressor of axon | somatic clone | adult stage | progressive | conditional phenotype of Pect^omb593

(Tsai et al., 2019)

SREBP^UAS.Exel, Scer\GAL4^GMR.PFa is a non-suppressor of optic cartridge | adult stage phenotype of Scer\GAL4^GMR.PFa, eas^KK102681

(Tsai et al., 2019)

SREBP^UAS.Exel/Scer\GAL4^GMR.PFa is a non-suppressor of retina | somatic clone | adult stage | progressive | conditional phenotype of Pect^omb593

(Tsai et al., 2019)

SREBP^UAS.Exel/Scer\GAL4^GMR.PFa is a non-suppressor of eye photoreceptor cell | somatic clone | adult stage | progressive | conditional phenotype of Pect^omb593

(Tsai et al., 2019)

SREBP^UAS.Exel/Scer\GAL4^GMR.PFa is a non-suppressor of rhabdomere | somatic clone | adult stage | progressive | conditional phenotype of Pect^omb593

(Tsai et al., 2019)

SREBP^UAS.Exel/Scer\GAL4^GMR.PFa is a non-suppressor of optic cartridge | somatic clone | adult stage | progressive | conditional phenotype of Pect^omb593

(Tsai et al., 2019)

SREBP^UAS.Exel, Scer\GAL4^GMR.PFa is a non-suppressor of axon | adult stage phenotype of Scer\GAL4^GMR.PFa, eas^KK102681

(Tsai et al., 2019)

SREBP^UAS.Exel, Scer\GAL4^GMR.PFa is a non-suppressor of eye photoreceptor cell | adult stage phenotype of Scer\GAL4^GMR.PFa, eas^KK102681

(Tsai et al., 2019)

Other

Statement

Reference

Pi3K92E^UAS.Tag:MYC, SREBP^UAS.Exel, Scer\GAL4^Bx-MS1096 has wing phenotype

(Porstmann et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of HLH106^{Scer\UAS.Exel} and Pi3K92E^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096 results in flies with severely deformed wings.

(Porstmann et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

8236

y¹ w¹¹¹⁸; P{UAS-SREBP.Exel}3

8237

P{UAS-SREBP.Exel}1, y¹ w¹¹¹⁸

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

HLH106^{Scer\UAS.Exel}

SREBP^{Scer\UAS.Exel}

SREBP^UAS.Exel

dSREBP^FL

(Lim et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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