FlyBase Allele Report: Dmel\E(br)72[Ebr72]

General Information

Symbol

Dmel\E(br)72^Ebr72

Species

D. melanogaster

Name

FlyBase ID

FBal0156615

Feature type

allele

Associated gene

E(br)72

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ward et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Ward et al., 2003)

some die during embryonic stage | recessive

(Ward et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygotes do not show a malformed leg phenotype. Homozygotes show 98 +/- 2% embryonic lethality. Homozygous embryos have no discernible mutant phenotype.

(Ward et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

E(br)72^Ebr72/E(br)72[+] is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

E(br)72^Ebr72/E(br)72[+] is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

7% of br¹ ; E(br)72^Ebr72/+ flies show a malformed leg phenotype. The predominant leg phenotype in br¹/Y ; E(br)72^Ebr72/+ flies is short, fat femurs and tibias. 0% of br⁵/+ ; E(br)72^Ebr72/+ flies show a malformed leg phenotype. 16% of E(br)72^Ebr72 Rho1^J3.8 double heterozygotes show a malformed leg phenotype in at least one leg. 5% of E(br)72^Ebr72 Rho1^k02107b double heterozygotes show a malformed leg phenotype in at least one leg. 6% of E(br)72^Ebr72 Rho1^E3.10 double heterozygotes show a malformed leg phenotype in at least one leg. 1% of E(br)72^Ebr72 RhoGEF2⁰⁴²⁹¹ double heterozygotes show a malformed leg phenotype in at least one leg. 3% of E(br)72^Ebr72 RhoGEF2^11-3 double heterozygotes show a malformed leg phenotype in at least one leg. 4% of E(br)72^Ebr72 zip^Ebr double heterozygotes show a malformed leg phenotype in at least one leg. 1% of E(br)72^Ebr72 zip¹ double heterozygotes show a malformed leg phenotype in at least one leg. 0% of E(br)72^Ebr72 zip^33-1 double heterozygotes show a malformed leg phenotype in at least one leg.

(Ward et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that enhances the br¹ malformed leg phenotype.

(Ward et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E(br)72

(Ward et al., 2003)

E(br)72^Ebr72

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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