FB2026_02 , released June 18, 2026
Allele: Dmel\Sec61αEbr165
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General Information
Symbol
Dmel\Sec61αEbr165
Species
D. melanogaster
Name
FlyBase ID
FBal0156622
Feature type
allele
Associated gene
Dmel\Sec61α
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ward et al., 2003)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      1% of heterozygotes show a malformed leg phenotype. Homozygotes show 100% embryonic lethality. Homozygous embryos show a naked cuticle phenotype and a highly penetrant dorsal open phenotype.

      (Ward et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      E(br)165[+]/Sec61αEbr165 is an enhancer of visible phenotype of br1

      (Ward et al., 2003)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      E(br)165[+]/Sec61αEbr165 is an enhancer of leg phenotype of br1

      (Ward et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      100% of br1 ; E(br)165Ebr165/+ flies show a malformed leg phenotype. The predominant leg phenotype in br1/Y ; E(br)165Ebr165/+ flies is short, fat tarsal segments with normal femurs and tibias. 2% of br5/+ ; E(br)165Ebr165/+ flies show a malformed leg phenotype. 15% of E(br)165Ebr165 Rho1J3.8 double heterozygotes show a malformed leg phenotype in at least one leg. 7% of E(br)165Ebr165 Rho1k02107b double heterozygotes show a malformed leg phenotype in at least one leg. 10% of E(br)165Ebr165 Rho1E3.10 double heterozygotes show a malformed leg phenotype in at least one leg. 7% of E(br)165Ebr165 RhoGEF204291 double heterozygotes show a malformed leg phenotype in at least one leg. 1% of E(br)165Ebr165 RhoGEF211-3 double heterozygotes show a malformed leg phenotype in at least one leg. 6% of E(br)165Ebr165 zipEbr double heterozygotes show a malformed leg phenotype in at least one leg. 6% of E(br)165Ebr165 zip1 double heterozygotes show a malformed leg phenotype in at least one leg. 1% of E(br)165Ebr165 zip33-1 double heterozygotes show a malformed leg phenotype in at least one leg.

      (Ward et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that enhances the br1 malformed leg phenotype.

      (Ward et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      E(br)165
      (Wang et al., 2007, Ward et al., 2003)
      E(br)165Ebr165
      Sec61αEbr165
      Name Synonyms
      Secondary FlyBase IDs
        References (2)