FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\vnΔEGF.UAS
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General Information
Symbol
Dmel\vnΔEGF.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0158526
Feature type
allele
Associated gene
Dmel\vn
Associated Insertion(s)
Carried in Construct
P{UAS-vn.ΔEGF}
Key Links
Transgenic product class
inframe_deletion
(Donaldson et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Donaldson et al., 2004)
Mutagen
in vitro construct
(Donaldson et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-vn.ΔEGF}
Cytology
Description

UAS regulatory sequences drive expression of vn residues 1-564 and 599-622 (this construct lacks the vn EGF domain).

(Donaldson et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
vn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of vnΔEGF.Scer\UAS under the control of Scer\GAL469B at 29oC results in partial loss of wing vein L4. Co-expression of vnΔEGF.Scer\UAS suppresses the extra wing vein phenotype caused by expression of vnScer\UAS.cSa under the control of Scer\GAL469B. The wing phenotype seen in adults expressing vnΔIg.Scer\UAS (from a weaker P{UAS-vn.ΔIg} insertion line) under the control of Scer\GAL469B are rescued by co-expression of vnΔEGF.Scer\UAS. Co-expression of vnΔEGF.Scer\UAS in animals expressing vnΔMR93-213.Scer\UAS (from a weak P{UAS-vn.ΔMR93-213} insertion line) under the control of Scer\GAL471B results in more animals surviving to adulthood and a reduction in the extra wing vein phenotype seen in these animals. The extra wing vein phenotype caused by expression of vnΔMR395-476.Scer\UAS under the control of Scer\GAL469B is suppressed by co-expression of vnΔEGF.Scer\UAS. The extra wing vein phenotype caused by expression of vnΔMR177-395.Scer\UAS under the control of Scer\GAL469B is not suppressed by co-expression of vnΔEGF.Scer\UAS.

      (Donaldson et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      vnΔEGF.Scer\UAS
      vnΔEGF.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)