FlyBase Allele Report: Dmel\trsn[EY06981]

General Information

Symbol

Dmel\trsn^EY06981

Species

D. melanogaster

Name

FlyBase ID

FBal0158549

Feature type

allele

Associated gene

Dmel\trsn

Associated Insertion(s)

P{EPgy2}trsn^EY06981

Carried in Construct

Also Known As

pEY06981

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Suseendranathan et al., 2007)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}trsn^EY06981

Cytology

Description

P{EPgy2}trsn^EY06981 is inserted 716bp downstream of the start codon in exon 5.

(Suseendranathan et al., 2007)

Insertion in the 3' exon.

(Claussen et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:10,479,391..10,479,391 [+]

(Liu et al., 2009, Suseendranathan et al., 2007, Claussen et al., 2006, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal jump response | recessive

(Suseendranathan et al., 2007)

abnormal sleep | adult stage | nutrition conditional

(Murakami et al., 2016)

abnormal starvation stress response | adult stage

(Murakami et al., 2016)

fertile

(Suseendranathan et al., 2007, Claussen et al., 2006, Gene Disruption Project members, 2001-)

viable

(Suseendranathan et al., 2007, Claussen et al., 2006, Gene Disruption Project members, 2001-)

Phenotype Manifest In

Detailed Description

Statement

Reference

Under 12:12 light:dark zeitgeber cycles, trsn^EY06981 homozygous mutants present increased average sleep time and decreased waking activity upon starvation conditions but not under normal diet conditions, as compared to wild-type controls; trsn^EY06981 homozygous mutants do not show the starvation-induced sleep deprivation and increased waking activity observed in wild-type controls.

(Murakami et al., 2016)

Homozygotes are viable and show no obvious morphological defects.

Homozygotes show normal geotatic, phototactic and olfactory response behaviours. However, homozygotes do show a significantly reduced benzaldehyde-induced jump response, demonstrating reduced motor activity.

Male and female fertility is normal in trsn^EY06981 homozygotes.

(Suseendranathan et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

16774

y¹ w^67c23; P{EPgy2}trsn^EY06981

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

translin^EY06981

trsn^EP

(Murakami et al., 2016)

trsn^EY06981

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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