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General Information
Symbol
Dmel\topiZ3-2139
Species
D. melanogaster
Name
FlyBase ID
FBal0158555
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C9776966T

Reported nucleotide change:

C1584T

Amino acid change:

Q522term | topi-PA

Reported amino acid change:

Q521term

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q521term.

Nucleotide substitution: C1584T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

topiZ3-2139/topiZ3-0707 heterozygote males show morphological defects of the nuclear lamina in stage S4-S6 spermatocytes (the lamina has more ballon-like shape, largely lacking the deformations that correlate with chromosome distribution seen in wild-type), while in stage S3 the lamina is of wild-type appearance.

topiZ3-2139/topiZ3-0707 mutant spermatocytes exhibit meiotic arrest and other defects, including bivalent chromosomes condensing to spherical shapes away from the nuclear periphery, and failure of the nucleolus to fully break down.

Chromosomes in mutant primary spermatocytes are partially condensed and are not close to the nuclear envelope (in contrast to wild-type primary spermatocytes where they are decondensed and adjacent to the nuclear envelop).

The testes of topiZ3-2139/topiZ3-2139 adult males contain germ cell cysts up to and including mature primary spermatocytes, but lack germ-cells in meiotic division or spermatid differentiation stages. Degenerating primary spermatocytes are present in the distal region of the testis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

From C.Zucker's collection of viable, male sterile lines.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)