FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ppkRNAi.UAS
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General Information
Symbol
Dmel\ppkRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0158779
Feature type
allele
Associated gene
Dmel\ppk
Associated Insertion(s)
Carried in Construct
P{UAS-ppk.RNAi}
Also Known As
UAS-ppk1-RNAi
Key Links
Transgenic product class
RNAi_reagent
(Xu et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Xu et al., 2004)
Mutagen
in vitro construct
(Xu et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-ppk.RNAi}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat of a 350bp fragment of ppk sequences.

(Xu et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ppk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ppkdsRNA.Scer\UAS driven by Scer\GAL4ppk.PG significantly reduces turning frequency (locomotor defects) in third instar larvae.

      (Gorczyca et al., 2014)

      Expression of ppkdsRNA.Scer\UAS under the control of Scer\GAL4109(2)80 results in defects in crawling behaviour in wandering larvae; the larvae show an increase in the time percentage spent on linear locomotion compared to controls and the duration of the linear locomotion is increased. The average direction change (direction change is defined as the difference in direction from one frame to the next in the analysis) is reduced compared to controls.

      (Xu et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ppkdsRNA.Scer\UAS under the control of Scer\GAL4109(2)80 can rescue the defects in crawling behaviour seen in Fmr14.L/Fmr14.L wandering larvae.

      (Xu et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ppkRNAi.UAS
      ppkdsRNA.Scer\UAS
      ppkdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)