FlyBase Allele Report: Dmel\mnb[EY14320]

General Information

Symbol

Dmel\mnb^EY14320

Species

D. melanogaster

Name

FlyBase ID

FBal0158938

Feature type

allele

Associated gene

Dmel\mnb

Associated Insertion(s)

P{EPgy2}mnb^EY14320

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}mnb^EY14320

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:17,884,699..17,884,699 [-]

(Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | third instar larval stage

(Shaikh et al., 2016)

decreased occurrence of cell division | third instar larval stage

(Shaikh et al., 2016)

fertile

(Gene Disruption Project members, 2001-)

viable

(Gene Disruption Project members, 2001-)

Phenotype Manifest In

larval brain | third instar larval stage

(Shaikh et al., 2016)

larval neuroblast | third instar larval stage

(Shaikh et al., 2016)

larval outer optic anlage | third instar larval stage

(Shaikh et al., 2016)

Detailed Description

Statement

Reference

mnb^EY14320/mnb^EY14320 mutants exhibit a significant decrease in neuroblast proliferation in the outer proliferation center and central brain of late third instar larvae, as compared to wild type.

(Shaikh et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

21430

y¹ w^67c23 P{EPgy2}mnb^EY14320 CG12985^EY14320

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DYRK1^EY14320

(Kanao et al., 2012)

mnb^EY14320

(Shaikh et al., 2016, Kanao et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close