FlyBase Allele Report: Dmel\emb[EY08770]

General Information

Symbol

Dmel\emb^EY08770

Species

D. melanogaster

Name

FlyBase ID

FBal0159261

Feature type

allele

Associated gene

Dmel\emb

Associated Insertion(s)

P{EPgy2}emb^EY08770

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}emb^EY08770

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:8,403,611..8,403,611 [+]

(Sowa et al., 2018, Yang et al., 2013, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Sowa et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of emb^EY08770 under the control of Scer\GAL4^GMR.PF does not induce any obvious eye phenotypes compared to controls.

(Sowa et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

emb^EY08770, Scer\GAL4^hs.2sev is an enhancer of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Suppressor of

Statement

Reference

emb^EY08770, Scer\GAL4^GMR.PF is a suppressor of abnormal eye color phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

emb^EY08770, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

emb^EY08770, Scer\GAL4^GMR.PF is a suppressor of increased cell death | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

emb^EY08770, Scer\GAL4^{elav.Switch.PO} is a suppressor of short lived phenotype of Hsap\ATXN3^70Q.UAS, Scer\GAL4^{elav.Switch.PO}

(Sowa et al., 2018)

emb^EY08770, Scer\GAL4^{elav.Switch.PO} is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\ATXN3^70Q.UAS, Scer\GAL4^{elav.Switch.PO}

(Sowa et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

emb^EY08770, Scer\GAL4^hs.2sev is an enhancer of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Suppressor of

Statement

Reference

emb^EY08770, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype and associated depigmentation and necrosis induced by the expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PF are slightly suppressed by the co-expression of emb^EY08770.

The decreased adult locomotion and decreased lifespan induced by the adulthood-only expression of Hsap\ATXN3^70Q.UAS under the control of Scer\GAL4^{elav.Switch.PO} and RU-486 treatment are partially suppressed by the co-expression of emb^EY08770.

(Sowa et al., 2018)

A emb^EY08770 background strongly enhances the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev-> Mmus\Gria1^Lc.Scer\UAS flies.

(Yang et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

19935

y¹ w^67c23; P{EPgy2}emb^EY08770/CyO