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General Information
Symbol
Dmel\dj-1βA286
Species
D. melanogaster
Name
FlyBase ID
FBal0159324
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A 6983bp piggyBac element insertion (PBac{5HPw+}dj-1βA286) is inserted in the third exon of dj-1β, at base pair 642 of the gene.

Insertion components
PBac{5HPw+}dj-1βA286
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

dj-1βA286/dj-1βA286 mutant flies display age-dependent motor deficits and a significantly shorter lifespan than wild-type flies, but do not display dopaminergic neurodegeneration.

dj-1βA286 mutant flies exhibit reduced climbing ability compared to control flies, almost from the first day of age. Although they show a premature loss of climbing activity, the declining rate of this activity over time is similar in dj-1βA286 flies and control flies.

dj-1βA286 mutant flies display a significantly shorter lifespan than control flies. The mean lifespan for dj-1βA286 flies is 38 days, while control flies exhibit a mean lifespan greater than 50. Also, the maximum lifespan is reduced in dj-1βA286 to 41 days, compared to 65 days in control flies.

dj-1βA286 mutant flies are more sensitive to paraquat treatment than age-matched control flies.

Flies homozygous for dj-1βA286 are fully viable, fertile, and phenotypically wild-type.

Homozygous dj-1βA286 mutants do not display a significant difference in DA neuron number compared to wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

dj-1βA286 is a suppressor of visible phenotype of RetMEN2B.GMR

Phenotype Manifest In
Suppressor of
Statement
Reference

dj-1βA286 is a suppressor of eye | adult stage phenotype of RetMEN2B.GMR

Additional Comments
Genetic Interactions
Statement
Reference

dj-1βA286 significantly suppresses the small rough eye phenotype in RetMEN2B.GMR flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)