FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dj-1βA286
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General Information
Symbol
Dmel\dj-1βA286
Species
D. melanogaster
Name
FlyBase ID
FBal0159324
Feature type
allele
Associated gene
Dmel\dj-1β
Associated Insertion(s)
PBac{5HPw+}dj-1βA286
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lavara-Culebras and Paricio, 2007)
Progenitor genotype
Associated Insertion(s)
PBac{5HPw+}dj-1βA286
Cytology
Description

A 6983bp piggyBac element insertion (PBac{5HPw+}dj-1βA286) is inserted in the third exon of dj-1β, at base pair 642 of the gene.

(Lavara-Culebras and Paricio, 2007)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dj-1βA286/dj-1βA286 mutant flies display age-dependent motor deficits and a significantly shorter lifespan than wild-type flies, but do not display dopaminergic neurodegeneration.

      (Lavara-Culebras et al., 2010)

      dj-1βA286 mutant flies exhibit reduced climbing ability compared to control flies, almost from the first day of age. Although they show a premature loss of climbing activity, the declining rate of this activity over time is similar in dj-1βA286 flies and control flies.

      dj-1βA286 mutant flies display a significantly shorter lifespan than control flies. The mean lifespan for dj-1βA286 flies is 38 days, while control flies exhibit a mean lifespan greater than 50. Also, the maximum lifespan is reduced in dj-1βA286 to 41 days, compared to 65 days in control flies.

      dj-1βA286 mutant flies are more sensitive to paraquat treatment than age-matched control flies.

      Flies homozygous for dj-1βA286 are fully viable, fertile, and phenotypically wild-type.

      Homozygous dj-1βA286 mutants do not display a significant difference in DA neuron number compared to wild-type.

      (Lavara-Culebras and Paricio, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      dj-1βA286 is a suppressor of visible phenotype of RetMEN2B.GMR

      (Aron et al., 2010)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      dj-1βA286 is a suppressor of eye | adult stage phenotype of RetMEN2B.GMR

      (Aron et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      dj-1βA286 significantly suppresses the small rough eye phenotype in RetMEN2B.GMR flies.

      (Aron et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DJ-1βA286
      (Sanz et al., 2017, Lavara-Culebras et al., 2010, Lavara-Culebras and Paricio, 2007)
      dj-1βA286
      Name Synonyms
      Secondary FlyBase IDs
        References (5)