dj-1βA286/dj-1βA286 mutant flies display age-dependent motor deficits and a significantly shorter lifespan than wild-type flies, but do not display dopaminergic neurodegeneration.
dj-1βA286 mutant flies exhibit reduced climbing ability compared to control flies, almost from the first day of age. Although they show a premature loss of climbing activity, the declining rate of this activity over time is similar in dj-1βA286 flies and control flies.
dj-1βA286 mutant flies display a significantly shorter lifespan than control flies. The mean lifespan for dj-1βA286 flies is 38 days, while control flies exhibit a mean lifespan greater than 50. Also, the maximum lifespan is reduced in dj-1βA286 to 41 days, compared to 65 days in control flies.
dj-1βA286 mutant flies are more sensitive to paraquat treatment than age-matched control flies.
Flies homozygous for dj-1βA286 are fully viable, fertile, and phenotypically wild-type.
Homozygous dj-1βA286 mutants do not display a significant difference in DA neuron number compared to wild-type.