FlyBase Allele Report: Dmel\cbc[e00083]

General Information

Symbol

Dmel\cbc^e00083

Species

D. melanogaster

Name

FlyBase ID

FBal0159480

Feature type

allele

Associated gene

Dmel\cbc

Associated Insertion(s)

PBac{RB}cbc^e00083

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{RB}cbc^e00083

Cytology

Description

P-element insertion in 3' UTR of cbc.

(Schmidt et al., 2022)

Allele components

Component

Use(s)

Inserted element

PBac{RB}

gene trap

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:13,483,741..13,483,741 [-]

(Gene Disruption Project members and Exelixis, 2005, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of pontocerebellar hypoplasia type 10

CEA

(Schmidt et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | third instar larval stage

(Schmidt et al., 2022)

abnormal neuroanatomy | third instar larval stage

(Schmidt et al., 2022)

decreased size | third instar larval stage

(Schmidt et al., 2022)

majority die during P-stage

(Schmidt et al., 2022)

partially lethal - majority die

(Schmidt et al., 2022)

Phenotype Manifest In

larval brain | third instar larval stage

(Schmidt et al., 2022)

Detailed Description

Statement

Reference

cbc^e00083 homozygous third instar larvae exhibit decreased crawling ability. Their brain lobes are smaller.

(Schmidt et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

17812

w¹¹¹⁸; PBac{RB}cbc^e00083/CyO

Kyoto

114642

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{neoFRT}42D PBac{RB}cbc^e00083 /CyO y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG5970^e00083

arr^e00083

(Bloomington Drosophila Stock Center, 2004.11.6)

cbc³

(Schmidt et al., 2022)

cbc^e00083

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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